Detailed Understanding of TOR Signaling Through Mikhail Blagosklonny

Being a leading cause of death in the health sector, cancer has claimed many lives. The puzzle behind its causative agent, cure and therapy has led to the contribution of several scientists, donors, physicians, therapists and researchers. Faced with the challenge to address these issues, organizations have merged to come up with treatment methods and therapies. Such is the input of Mikhail Blagosklonny, a research scientist. Being a specialist in biology and cancer treatment as well as therapies, Mikhail has been instrumental in the battle against cancer. Most of his works have revolutionary transformed the medical landscape.


Blagosklonny is a recognized oncology research scientist. His works extend to authoring more than 150 articles on cancer cell biology. Aside from that, Mikhail has been an assistant author for multiple book chapters as well as reviews based on the molecular composition of cancer cells and their behavior in healthy human cells. Mikhail has given detailed research insight on cancer cells including the cycle involved in apoptosis and autophagy. Through his widely cited insight, Mikhail has focused on the theory of aging through molecular study.


Towards this end, Mikhail was of the opinion that TOR Signaling, also known as target of rapamycin has a significant input in prolonging the life cell of the human body. This is because through TOR Signaling, there is a delay in autophagy and an increase in protein synthesis. Mikhail further stated that it is crucial for medical practitioners to understand these processes. This is because with detailed understanding, treatment becomes relatively easier. Additionally, the processes have a slowing effect on age-related diseases. According to Blagosklonny, too much rapamycin contribute to the inhibition of autophagy, leading to cancerous tumors. Mikhail is hopeful that these processes will be understood in detail with the aim of finding painless and reliable treatment options for terminal and age-related illnesses. To Mikhail, it is vital to invest in the understanding of these processes.


Blagosklonny’s input in the medical field extends beyond research works. As a scholar, he is recognized for the vast experience he harbors in research institutions. Mikhail’s experience extends to Roswell Institute of Research where he is a highly regarded professor of oncology. His appointment in 2009 was influenced by his experiences. He also landed an executive role at the Ordway Institute of Research where he served as a research scientist. In 2002, Mikhail Blagosklonny’s academic credentials supported his role as a lead specialist in experimental medicine. Blagosklonny was thence appointed as a medical associate professor for the New York Medical College.


Currently, Blagosklonny is a lead editor for Oncotarget. This is a peer-reviewed journal that focuses on sharing vital information concerning diseases and the proposed treatments. Through Oncotarget, Blagosklonny, Oncotarget addresses arising medical issues. These issues are then published on the journal. Depending on the demand, the articles can be printed for weekly use. Blagosklonny insists that as time moves, there are more discoveries made towards treating diseases. Mikhail has extensively invested in finding curative measures for cancer and diseases that are related to old age.

Andrew Rolfe: Developing the Ubuntu Fund to Help Children

Andrew Rolfe is the chairman of the Ubuntu fund. He is a major asset to the company as he is always looking for ways to expand and improve the opportunities for the children who are disadvantaged. In May of 2017, the organization had hoped to raise around nine hundred thousand dollars. The money that this organization raises is aimed at benefiting the school campus of the fund. This school is found in Port Elizabeth, South Africa. They have numerous projects, and one of them is a pediatric clinic that is a part of the school campus. The school aims at reaching to those who are disadvantaged in the society.

During the Annual Ubuntu Fund Gala Dinner in May, Andrew Rolfe had the pleasure of treating those who attended to some tasty food and also a performance by the Xhosa choir. Two students who had been assisted by this fund were among the special guests. After dinner was over, one student, Sinesipho Rabidyani was able to speak to the crowd. She explained her story that captured the hearts of the guests. She explained how the fund had helped her get the education she needed and also how she was mentored to become who is.

Andrew Rolfe is the current chairperson of the fund. He is also the M.D. for the TowerBook Capital Partners. At this organization, his primary focus is the hospitality and acquiring food service. He also deals with the retail business and the opportunities for investment. Before he was able to take this position, he attended the University of Oxford. Here, he was able to earn a degree in Philosophy, Economics, and Politics. He went to Harvard School of Business , where he was able to earn a degree in Master of Business Administration.

Rolfe was able to become the president of the International Division of Gap. As the president, he was the one who oversaw the operations in Japan, Germany, France and also the United Kingdom. He was also the one who was responsible for the strategies of international growth. Before he was able to take this position, he had gained enough experience as he headed several huge firms. Some of these companies include the True Religion Apparel.


Clay Siegall; the Mastermind behind Seattle Genetics’ Success Story

To succeed in any venture, factors such as capital, market, and quality of one’s products plays a crucial role in influencing the level of success. However, without a touch of passion or in other words, interest in the venture, trusts me you can expect nothing but total fail. Ask Clay Siegall, founder of Seattle Genetics, and he will accord to the statement.

During an interview with Inspirery, the successful doctor admitted that his keen interest in improving the cancer treatment therapies saw him launch Seattle Genetics. Clay Siegall had lost a close relative from the painful cancer treatments hence felt the urge to do something to improve the procedures.

During the interview, Clay pointed out that Seattle makes money through a couple of ways. Seattle Genetics garner considerable revenue from the sale of its drugs such as the ADCentris that is doing well as an FDA-approved antibody. Also, Seattle licenses its formulated technologies through which it gathers sufficient revenue.

Clay Siegall noted that the success is a step by step process that may take even longer than expected. According to Clay, it took Seattle almost ten years to become profitable, a period he said to have utilized to establish substantial grounds of the Seattle Genetics we know today. Seattle understands the basics of business which are customers and remaining the best. Today, Seattle is known for recruiting the qualified and talented staff in their team to handle the sale of its products. There is nothing that feels amazing than selling a product you are well informed about hence having qualified staff has seen Seattle widen its market area.

About Clay Siegall

Currently, Siegall serves as the President and CEO of Seattle Genetics. Besides, the successful doctor serves on Seattle’s board of directors. Seattle is a biotech firm that works day and night tirelessly to advance various therapy drugs. Seattle was launched in 1998, and under Siegall‘s leadership, the company has grown from a skeleton to a distinguished firm it is today.

Dr. Clay Siegall joined the University of Maryland where he earned BS in Zoology before joining the University of George Washington where he received a PhD in Genetics. Before venturing on his own, the successful doctor used to work with the Bristol-Myers Squibb Pharmaceutical Research Institute and the National Cancer Institute. Besides, Dr. Clay Siegall writes scientific papers while away from the work environment

How Sheriff Joe Arpaio’s Rampant Corruption Helped to Create the Frontera Fund

On the evening of October 18, 2007, armed police acting under orders from Maricopa County Sheriff Joe Arpaio’s notorious “Selective Enforcement Unit” hunted down and arrested Mike Lacey and Jim Larkin, two Village Voice Media executives.


It turned out to be a day that will live in infamy.


Deputies forcibly removed the pair from their respective homes in the Phoenix area and jammed them into dark, unmarked SUVs with tinted windows and Mexican license plates. Under the watchful eye of “America’s Toughest Sheriff” Joe Arpaio, Lacey and Larkin were later booked into two separate jails.


The grim details were brought to light by the Phoenix New Times, a local newspaper that had a history of exposing Arpaio’s misdeeds on numerous occasions previously. The paper had run stories on Arpaio’s anti-Mexican fear-mongering, his retaliatory abuses of power against law enforcement critics, financial irregularities and egregious mismanagement in the sheriff’s office, and much more.


It’s no surprise, then, that Arpaio (at least ostensibly) targeted Lacey and Larkin after they had written a cover story in the paper critical of Arpaio. The article detailed the steps taken by Arpaio and his allies to issue grand jury subpoenas, seeking details about the newspaper’s staff members and readers.


When Lacey and Larkin exposed the plot to suppress the media through grand jury subpoenas, they ended up in jail. It took a monumental outcry across the state and national media attention to free the two men, who were back home within 24 hours with all charges dropped.


Years later after much legal wrangling, a court found that grand jury subpoenas issued for Lacey and Larkin were invalid due to the prosecution side-stepping proper legal procedures. The court also found that the pair were arrested and detained without probable cause.


This paved the way for a $3.7 million settlement paid by Maricopa County in 2013 to Lacey and Larkin. The pair earmarked the settlement money to create the Frontera Fund, an organization which seeks to benefit the Hispanic community which has suffered most from racial tensions and civil rights abuses in Arizona.


After the settlement, Larkin said, “I cannot think of a more deserving group than those Mexican immigrants who brave unimaginable peril in the desert to travel to Arizona for work and economic opportunity.”


As for Lacey, his post-settlement sentiments were similar: “Sheriff Joe Arpaio demonized and detained Mexican migrants as well as anyone with brown skin” he observed. “The people of Arizona are better than this…we are all migrants.”


Mark Hutchinson Is Helping Bring the Wilderness Back to Humanity

A lot of people talk about the environment. Likewise, most people know that there’s a significant amount of unique biodiversity which is in danger of disappearing forever. However, it’s rare to find someone actually doing something to save the natural world. Mark Hutchinson is one of the people trying to do so. And in the process he’s helping to make it easier for others to do the same. Learn more:


However, to understand Mark’s work one must first understand his background. Mark grew up in the wilds of Australia. It’s a beautiful land filled with natural wonders. It’s easy to see why he was struck with wanderlust at an early age. As soon as he was able, Mark ventured out into the world to see just what was out there. What he discovered was some amazing wilderness. But he also discovered something amazing about the experience of entering into these areas. Mark noticed that people rediscovered a connection to nature when they ventured into these wild areas. He called it a rewilding, and it served as an important point of his later work. Learn more:


Mark’s biggest adventure into rewilding has come about through something called Wild Ark. It’s not only about rewilding the human spirit. The venture is also involved with ensuring that the wilderness itself can be rewilded. The areas Mark focuses on are those which have unique biodiversity that needs extra protection. Mark helps keep these areas safe and untouched by partnering native guides with Wild Ark. By doing so he’s able to help arrange eco friendly vacations for people into these pristine natural wonderlands. Learn more:


The most amazing thing about the venture is that it’s able to help every single party involved with the process. The local economy is both enriched, and recentered around the idea of protecting the nearby wilderness. Vacationers are able to experience the wonders of these beautiful areas. At the same time they’re able to know that they’re doing so in a safe and respectful manner thanks to the involvement of native guides.


The end goal is to preserve and rewild natural environments. At the same time wildlife corridors can be established between different natural parks. And along the way everyone involved can take pride in knowing that they’re not only having fun, but also helping the world become a better place.


Kate Hudson’s Fabletics Keeping Pace with Amazon

To be able to keep pace with Amazon, you need to be selling a substantial amount in the fashion e-commerce market. The reason being is that there are thousands of competitors in this niche, each trying for the same customer, yet Amazon takes in 20 percent of all the sales. That being said, Kate Hudson’s Fabletics is not going to let those numbers scare them from their charge to the front of the pack. In a little under three years, Kate Hudson’s Fabletics has already sold $250 million in women’s workout clothing and active-wear.


To be able to truly understand the success of this athleisure brand, listen to how Hudson gives credit to her company growth. Instead of giving credit to high-quality or her celebrity name, it all comes down to reverse showrooming and her membership plan. To see what these to components are doing together to drive sales, we begin the quest for answers at the local mall inside the Fabletics retail stores. Women are buying active-wear off the racks, taking lifestyle quizzes, trying on all the workout apparel, and window-shopping too. You will not see Fabletics sales associates pressuring their customer to buy in the store, here is the reason why.


In order to be a dominant force in the fashion e-commerce market and compete with Amazon, you need a killer website. The minute you try anything on inside the Fabletics retail stores, you will notice it gets transferred right to your online account. What this does is make it easier to not only pick up where you left off, you can go impulse shopping because you don’t have to wait for a delivery to see how the active-wear fits you. So these women are hitting the online store from their mobile devices, and they are buying leggings, yoga pants, and tank tops in bulk.


The membership perks when you are a customer at Kate Hudson’s Fabletics are vast. In addition to free shipping for those online orders, customers get discounted apparel pricing and the help of a personal shopping assistant. It appears that Kate Hudson’s Fabletics is the total package here, offering female shoppers all the perks they could want, with a little pampering sprinkled in for good measure. If Amazon is not worried yet that they have some real competition, they may not be able to make changes fast enough when this company rolls right on by.

Goettl Air Conditioning Continues Growth Pattern

Your home air conditioning system is one of the most important parts of your home. Having a strong HVAC system in your home will help to ensure that you are able to control the conditions of your home and save money on your utility bills. For those that are in the southwest United States, one of the leading providers of home HVAC installation and repair services is Goettl Air Conditioning.

Goettl Air Conditioning is one of the largest and oldest air conditioning and heating service providers in the southwest United States. The company has been in business for decades and has seen a lot of expansion in the past few years. While the company was still considered a small business just ten years ago, they have made a number of big purchases and expansions in recent years.

In the past 12 months, Goettl Air Conditioning has purchased at least three different local HVAC companies in the southwest United States. While the company has always had a strong presence in southern California, Goettl Air Conditioning is now a much larger participant in the Arizona, Nevada, and southern Utah markets. The company is also looking for ways to continue to expand in the coming years. They are considering expanding further into Nevada and Utah in the coming year and may also target some strategic markets in Texas and New Mexico. Within the next decade, the company hopes to be the largest provider in this region of the country as they look for ways to further expand.

While Goettl Air Conditioning has spent a lot of effort in growing the company, it is continuing to find ways to improve the service that it provides to existing customers. The company is well known for providing a great level of service and can help with all areas of the HVAC industry. Some of the top services they provide are installation, maintenance, and repair for both residential and commercial properties.


Philadelphia’s New Salary History Law Featuring Karl Heideck

Karl Heideck
Karl Heideck

A new law in Philadelphia is causing a large group of employers to sweat. In Early 2017 Mayor Jim Kenney signed off on the new salary history law making Philly a pioneer in employee rights. Now companies wanting to do business in the city may face fines for inquiring as to how much the people they employee have made in the past.

A few weeks before the new rule was set to go into effect, Philadelphia’s Chamber of Commerce stood up to argue against it. They managed to get the new salary rule postponed for a time but in early June of 2017 the lawsuit was thrown out. The original complaint had failed to show which of the chamber members would suffer due to the legislation.


Lawsuits filed by the chamber would require specifying companies that currently rely on inquiring about the salary history of employees during the interview process. The salary history law has an uncertain time ahead. In the mean time employers have to be made aware of the consequences of prying directly into past employee financial relationships.

This story highlights the legal realities faced by business owners everyday. A new law is passed and business owners have to adapt to survive. The only way make it to the top is to surround yourself with good people that possess the right skills. One of those people is Karl Heideck, a contract attorney.

Karl Heideck has been listed by Hire Counsel since April 2015. Before that he fought for equality all around Philly. His skills range from file clerking and customer service to practicing before and after trial clean up. With 8 years of experience Karl Heideck is a capable and trustworthy advocate.

Today, Karl Heideck offers services that range from advising on how the law affects his client and scouting out potential risk to economic security to dogged advocacy in all things commercial litigation. I for one believe that with lawyers like Karl Heideck out there that justice isn’t just a fantasy, but a promise.

Find more details about Karl Heideck:

George Soros Looks To The Grassroots To Fight The Rise Of Donald Trump

The victory of Donald Trump during the 2016 U.S. Presidential election came as something of a shock for most people who had believed polls stating Democrat Hillary Clinton would win election to the White House. George Soros has been a major Democrat donor for many years and returned to the U.S. political scene in 2015 in a major way with more than $25 million donated to Clinton and her Super PAC’s; prior to his return to the U.S. political landscape George Soros had spent much of the last decade seeking to bring democracy to the world through his own Open Society Foundations.

In returning to the political community of the U.S. he had remained on the periphery of since donating over $27 million to the campaign of John Kerry in 2004, George Soros showed just how important he felt the global political landscape was in 2016. Advisors for George Soros have recently revealed the Hungarian born hedge fund legend has rarely been as engaged politically as he has seemed in 2015 and 2016 because of the changing political environment; Soros has been closely monitoring global events in the European Union after becoming concerned by the refugee crisis on Forbes and the Brexit decision in the U.K. The work of the Open Society Foundations to educate individuals about democracy has also seen George Soros clash with Russian officials who did not feel their citizens needed to understand more about democracy.

As a hedge fund manager George Soros has amassed a personal fortune reported to have reached $25 million after beginning his adult life as a refugee from Communist rule in his native Hungary, where he had also survived the Holocaust during the Nazi occupation of the country. Soros has also made a recent return to active trading with his own hedge fund and felt the need for greater democratic and liberal leadership on Snopes was an important factor at a time when the man who made $1 billion in a single day by the devaluation of the British Pound in the 1990s feels the rise of right wing policies poses a major threat to open societies around the world.

The response of George Soros to the election of Donald Trump was to change his own schedule and attend the Democracy Alliance meeting of wealthy Democrat donors and politicians in Washington D.C. George Soros understands the need for swift action to fight the policies being discussed by Donald Trump, such as the construction of a border wall with Mexico and the repeal of the Affordable Care Act; Soros and other Democrat’s came together under the Democracy Alliance banner to discuss their own role in future elections as the use of Super PAC’s has become controversial for the public. A major part of the Democracy Alliance event was spent discussing a strategy for defeating the policies of the Republican party from the very first day of the Trump Administration that could destroy the legacy of President Obama just days after he leaves office.

Join Brown Modelling Agency During Open Call Every Thursday to Discover Career Opportunities as a Model or Actor

Justine Brown and Michael B. Bonne’ collectively possess over ten years of experience helping to develop children and millennials. The two business owners have expertise for the development of actors and models. Brown Agency has introduced some of our very best models to walk the runways at Dallas Fashion Week, New York Fashion Week, and Miami Swim Week. The agency hosts Open Call every Thursday for inspiring talents to explore opportunities with top brands and companies without the need to schedule an appointment.

Popular brands, including Louis Vuitton, L’Oréal, and Dell uses our modelling and acting services for advertising and promotional campaigns. We work with reputable companies in the media, fashion, entertainment, and advertising industries. Brown Modelling Agency has created a presence in Los Angeles, CA, and Austin and Dallas, TX. The agency is open between the hours of 3:00 pm and 4:00 pm every Thursday afternoon. Bring several photographs of yourself or a portfolio (not required) and resume.

Brown Agency is controlled by Justin Brown, previous president of Wilhelmina, an Austin-based talent agency. While working for Wilhelmina, he merged the company with acting talent agency, Heyman Talent-South. The merger enables Brown Model Agency to increase its growth and offer acting, modeling, and other talent services. Justin founded Wilhelmina in early 2010 and changed its name five years later to create a new brand for the company. To learn more about opportunities, visit us online at or on our Facebook page and provide your contact information.